12/15/2023 0 Comments Ambify half life![]() These drugs are considered in turn, as are clinically important issues related to their use. Some of these drugs have active metabolites with even longer half-lives than those of the parent drugs. Some of these drugs have long half-lives only because of the contribution of their active metabolites. These include the benzodiazepines chlordiazepoxide and diazepam, the antidepressants fluoxetine and vortioxetine, the antipsychotics aripiprazole, brexpiprazole, cariprazine, and penfluridol, and the dementia drugs donepezil and memantine. ![]() Many drugs in psychiatry have long half-lives that extend for 2 days or longer examples are listed in Table 1. For example, the antibacterial agent oritavancin has a half-life of about 16 days, the antimalarial agent mefloquine has a half-life of 14–41 days, and the antiarrhythmic drug amiodarone has a half-life of 21–78 days 2 whereas values stated for these drugs and for others in the rest of this article would depend on the source consulted, the variation across sources is usually modest. Other clinical issues related to drugs with long half-lives include the relevance of occasional missed doses, the possibility of once-weekly dosing, and the need for pregnancy planning. They also take long to wash out this is an advantage because the risk of drug withdrawal or discontinuation syndromes is small, and a disadvantage if rapid washout is desired for any reason, including the experience of drug adverse effects or toxicity, or the discovery of an unplanned pregnancy. Psychotropic drugs with long half-lives take long to reach steady state this is seldom a problem. Other drugs with long half-lives that psychiatrists may prescribe include levothyroxine and zonisamide. Examples are chlordiazepoxide, diazepam, fluoxetine, vortioxetine, aripiprazole, brexpiprazole, cariprazine, penfluridol, donepezil, and memantine. Many psychotropic drugs and their active metabolites, if any, have very long half-lives that extend for 2 days or longer. The half-life of a drug is the time taken for the blood level of the drug to fall by half, provided that no more doses of the drug are administered in the intervening period.
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